Downregulation of MicroRNA-145 Caused by Hepatitis B Virus X Protein Promotes Expression of CUL5 and Contributes to Pathogenesis of Hepatitis B Virus-Associated Hepatocellular Carcinoma | Zendy

Feng Gao | Zendy; Xiaoyu Sun | Zendy; Likun Wang | Zendy; Shunxiong Tang | Zendy; Changqing Yan | Zendy

Open Access

Downregulation of MicroRNA-145 Caused by Hepatitis B Virus X Protein Promotes Expression of CUL5 and Contributes to Pathogenesis of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Author(s) -

Feng Gao,

Xiaoyu Sun,

Likun Wang,

Shunxiong Tang,

Changqing Yan

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438522

Subject(s) - downregulation and upregulation , hepatocellular carcinoma , pathogenesis , microrna , hepatitis b virus , virology , virus , cancer research , biology , medicine , immunology , gene , genetics

Hepatitis B viral infection-induced hepatocellular carcinoma (HCC) is a major threat to human health in China. Hepatitis B virus X protein (HBX), an HBV protein, has been reported to be involved in regulating the cellular activities of the host cells and is responsible for HCC oncogenesis.

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