Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling | Zendy

Yinghua Li | Zendy; Yunpeng Xie | Zendy; Dan Cui | Zendy; Yanni Ma | Zendy; Linlin Sui | Zendy; Chenyang Zhu | Zendy; Hui Kong | Zendy; Ying Kong | Zendy

Open Access

Osteopontin Promotes Invasion, Migration and Epithelial-Mesenchymal Transition of Human Endometrial Carcinoma Cell HEC-1A Through AKT and ERK1/2 Signaling

Author(s) -

Yinghua Li,

Yunpeng Xie,

Dan Cui,

Yanni Ma,

Linlin Sui,

Chenyang Zhu,

Hui Kong,

Ying Kong

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000438518

Subject(s) - epithelial–mesenchymal transition , osteopontin , protein kinase b , cancer research , cell migration , metastasis , angiogenesis , extracellular matrix , pi3k/akt/mtor pathway , cell growth , cancer cell , endometrial cancer , gentamicin protection assay , biology , signal transduction , cancer , chemistry , cell , microbiology and biotechnology , medicine , immunology , genetics

Osteopontin (OPN) is an Extracellular Matrix (ECM) molecule and is involved in many physiologic and pathologic processes, including cell adhesion, angiogenesis and tumor metastasis. OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. In this study, we examined the significance of OPN in endometrial cancer.

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