Status Quo and Prospect of Colorectal Animal Models: Application of Transgenic Technology

Colorectal cancer (CRC) is one of the most common malignant diseases and brings about serious damage to the human body. Presently, the incidence of CRC ranks third among the malignant tumors, and its 5-year survival rate is only about 50%. In recent years, more and more studies have focused on the application of transgenic technology in CRC research in vivo, which involves a great number of genes significantly related to the occurrence and development of CRC. The core of transgenic technology refers to the host chromosome gene accepting exogenous genes, which integrate into the host chromosome expressing it stably, followed by transmission to the next generations. Here, we will present a brief review of the related technologies used in transgenic animal models and provide an overview of the application of transgenic animal models in CRC research.