Inflammation-Induced Expression of the Alarmin Interleukin 33 Can Be Suppressed by Galacto-Oligosaccharides | Zendy

Kim A.T. Verheijden | Zendy; Peyman Akbari | Zendy; Linette E. M. Willemsen | Zendy; Aletta D. Kraneveld | Zendy; Gert Folkerts | Zendy; Johan Garssen | Zendy; Johanna FinkGremmels | Zendy; Saskia Braber | Zendy

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Inflammation-Induced Expression of the Alarmin Interleukin 33 Can Be Suppressed by Galacto-Oligosaccharides

Author(s) -

Kim A.T. Verheijden,

Peyman Akbari,

Linette E. M. Willemsen,

Aletta D. Kraneveld,

Gert Folkerts,

Johan Garssen,

Johanna FinkGremmels,

Saskia Braber

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000437327

Subject(s) - interleukin 33 , inflammation , immunology , interleukin , medicine , biology , chemistry , cytokine

The alarmin interleukin 33 (IL-33) and its receptor ST2 play an important role in mucosal barrier tissues, and seem to be crucial for Th2-cell mediated host defense. Galacto-oligosaccharides (GOS), used in infant formulas, exhibit gut and immune modulatory effects. To enhance our understanding of the immunomodulatory capacity of GOS, this study investigated the impact of dietary GOS intervention on IL-33 and ST2 expression related to intestinal barrier dysfunction and asthma.

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