The Basophil Activation Test: A Sensitive Test in the Diagnosis of Allergic Immediate Hypersensitivity to Pristinamycin | Zendy

Sébastien Viel | Zendy; Lorna Garnier | Zendy; Elodie Joly | Zendy; Paul Rouzaire | Zendy; Audrey Nosbaum | Zendy; P. Pralong | Zendy; Amélie Faudel | Zendy; Catherine Rioufol | Zendy; Françoise Bienvenu | Zendy; Jacques Bienvenu | Zendy; F. Bérard | Zendy

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The Basophil Activation Test: A Sensitive Test in the Diagnosis of Allergic Immediate Hypersensitivity to Pristinamycin

Author(s) -

Sébastien Viel,

Lorna Garnier,

Elodie Joly,

Paul Rouzaire,

Audrey Nosbaum,

P. Pralong,

Amélie Faudel,

Catherine Rioufol,

Françoise Bienvenu,

Jacques Bienvenu,

F. Bérard

Publication year - 2015

Publication title -

international archives of allergy and immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.696

H-Index - 100

eISSN - 1423-0097

pISSN - 1018-2438

DOI - 10.1159/000435812

Subject(s) - basophil activation , allergy , medicine , gold standard (test) , immunology , context (archaeology) , immunoglobulin e , basophil , biology , antibody , paleontology

Immediate hypersensitivity (IHS) reactions to macrolides and to macrolide-derived antibiotics like pristinamycin are uncommon. In this context, there is little data available to appreciate the true value of biological tools regarding the diagnosis of immediate allergy to pristinamycin. Here we assess the clinical usefulness of the basophil activation test (BAT) to differentiate allergic from nonallergic IHS to pristinamycin. Thirty-six patients were tested with skin tests as the gold standard and BAT. The BAT achieved a sensitivity of 76% and a specificity of 100%, implying an absence of false positive results. Multicenter studies remain to be performed to better define the sensitivity, specificity and interlaboratory variation of BAT in the diagnosis of allergy to pristinamycin and macrolides.

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