Immunoglobulins in Neonates with Rhesus Hemolytic Disease of the Fetus and Newborn: Long-Term Outcome in a Randomized Trial
Author(s) -
Jeanine M.M. van Klink,
Suzanne J. van Veen,
Vivianne E.H.J. SmitsWintjens,
Irene T.M. Lindenburg,
Monique Rijken,
Dick Oepkes,
Enrico Lopriore
Publication year - 2015
Publication title -
fetal diagnosis and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 60
eISSN - 1421-9964
pISSN - 1015-3837
DOI - 10.1159/000434718
Subject(s) - medicine , pediatrics , randomized controlled trial , exchange transfusion , cerebral palsy , placebo , incidence (geometry) , pregnancy , surgery , physical therapy , physics , alternative medicine , pathology , biology , optics , genetics
Prophylactic intravenous immunoglobulin (IVIg) does neither reduce the need for exchange transfusion nor the rates of other adverse neonatal outcomes in neonates with rhesus hemolytic disease of the fetus and newborn (rhesus HDFN) according to our randomized controlled trial analysis. Our objective was to assess the long-term neurodevelopmental outcome in the children included in the trial and treated with either IVIg or placebo.
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