Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid Mice | Zendy

Denise Zwanziger | Zendy; Helena Rakov | Zendy; K Engels | Zendy; Lars C. Moeller | Zendy; Dagmar F�hrer | Zendy

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Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid Mice

Author(s) -

Denise Zwanziger,

Helena Rakov,

K Engels,

Lars C. Moeller,

Dagmar F�hrer

Publication year - 2015

Publication title -

european thyroid journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.23

H-Index - 10

eISSN - 2235-0802

pISSN - 2235-0640

DOI - 10.1159/000431316

Subject(s) - claudin , euthyroid , endocrinology , medicine , bone canaliculus , western blot , excretion , tight junction , thyroid , biology , biochemistry , gene , microbiology and biotechnology

In the liver the tight junction protein claudin-1 plays an important role in bile secretion by maintaining the paracellular barrier of bile canaliculi and the bile duct. A diminished bile excretion has been found in hypothyroid patients, and the prevalence of gallstones is increased in hypothyroidism. This association, however, only applies for men and is in contrast to the well-established female preponderance of biliary disease in the general population.

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