Complement in Lupus Nephritis: New Perspectives | Zendy

Lihua Bao | Zendy; Patrick N. Cunningham | Zendy; Richard J. Quigg | Zendy

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Complement in Lupus Nephritis: New Perspectives

Author(s) -

Lihua Bao,

Patrick N. Cunningham,

Richard J. Quigg

Publication year - 2015

Publication title -

kidney diseases

Language(s) - English

Resource type - Journals

eISSN - 2296-9381

pISSN - 2296-9357

DOI - 10.1159/000431278

Subject(s) - complement system , immunology , lupus nephritis , decay accelerating factor , classical complement pathway , alternative complement pathway , pathogenesis , complement factor b , complement deficiency , immune complex , systemic lupus erythematosus , complement receptor , immune system , eculizumab , nephritis , complement factor i , complement component 5 , biology , medicine , disease , pathology

Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by loss of tolerance to self-antigens, the production of autoantibodies and deposition of complement-fixing immune complexes (ICs) in injured tissues. SLE is characterized by a wide range of clinical manifestations and targeted organs, with lupus nephritis being one of the most serious complications. The complement system consists of three pathways and is tightly controlled by a set of regulatory proteins to prevent injudicious complement activation on host tissue. The involvement of the complement system in the pathogenesis of SLE is well accepted; yet, its exact role is still not clear.

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