Pharmacological Modulation of Mucosa-Related Impairment of β-Adrenoceptor-Mediated Relaxation in Human Detrusor | Zendy

Stefan Propping | Zendy; Melanie Roedel | Zendy; Manfred P. Wirth | Zendy; Ursula Ravens | Zendy

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Pharmacological Modulation of Mucosa-Related Impairment of β-Adrenoceptor-Mediated Relaxation in Human Detrusor

Author(s) -

Stefan Propping,

Melanie Roedel,

Manfred P. Wirth,

Ursula Ravens

Publication year - 2015

Publication title -

urologia internationalis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.771

H-Index - 53

eISSN - 1423-0399

pISSN - 0042-1138

DOI - 10.1159/000431260

Subject(s) - carbachol , endocrinology , detrusor muscle , medicine , receptor antagonist , antagonist , candesartan , receptor , chemistry , urinary bladder , angiotensin ii

The mucosa of human detrusor strips impairs catecholamine-induced relaxation. In order to elucidate which signal transduction pathways are involved in this cross talk between the mucosa and detrusor, we have studied the effects of several pharmacological agonists and antagonists on noradrenaline-mediated relaxation in intact and mucosa-denuded detrusor strips.

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