Promoter Methylation and BDNF and DAT1 Gene Expression Profiles in Patients with Drug Addiction | Zendy

Dor Mohammad Kordi-Tamandani | Zendy; Shahrad Tajoddini | Zendy; Farzaneh Salimi | Zendy

Open Access

Promoter Methylation and BDNF and DAT1 Gene Expression Profiles in Patients with Drug Addiction

Author(s) -

Dor Mohammad Kordi-Tamandani,

Shahrad Tajoddini,

Farzaneh Salimi

Publication year - 2015

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000430465

Subject(s) - brain derived neurotrophic factor , dopamine transporter , addiction , neurotrophic factors , methylation , epigenetics , dopaminergic , medicine , psychology , dopamine , biology , gene , neuroscience , genetics , receptor

Drug addiction is a brain disorder that has negative consequences for individuals and society. Addictions are chronic relapsing diseases of the brain that are caused by direct drug-induced effects and persevering neuroadaptations at the epigenetic, neuropeptide and neurotransmitter levels. Because the dopaminergic system has a significant role in drug abuse, the purpose of this study was to analyze the methylation and expression profile of brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in individuals with drug addiction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research