Endothelial Cell Autophagy in Atherosclerosis is Regulated by miR-30-Mediated Translational Control of ATG6 | Zendy

Tao Zhang | Zendy; Feng Tian | Zendy; Jing Wang | Zendy; Jing Jing | Zendy; Shanshan Zhou | Zendy; Yundai Chen | Zendy

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Endothelial Cell Autophagy in Atherosclerosis is Regulated by miR-30-Mediated Translational Control of ATG6

Author(s) -

Tao Zhang,

Feng Tian,

Jing Wang,

Jing Jing,

Shanshan Zhou,

Yundai Chen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430402

Subject(s) - autophagy , microbiology and biotechnology , endothelial stem cell , endothelial dysfunction , microrna , cd31 , biology , chemistry , apoptosis , cancer research , endocrinology , in vitro , angiogenesis , biochemistry , gene

Endothelial cell injury and subsequent death play an essential role in the pathogenesis of atherosclerosis. Autophagy of endothelial cells has a protective role against development of atherosclerosis, whereas the molecular regulation of endothelial cell autophagy is unclear. MicroRNA-30 (miR-30) is a known autophagy suppressor in some biological processes, while it is unknown whether this regulatory axis may be similarly involved in the development of atherosclerosis. Here, we aimed to answer these questions in the current study.

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