Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262 | Zendy

Hong Bao | Zendy; Fengying Gao | Zendy; Guogang Xie | Zendy; Zhenwei Liu | Zendy

Open Access

Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262

Author(s) -

Hong Bao,

Fengying Gao,

Guogang Xie,

Zhenwei Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430393

Subject(s) - downregulation and upregulation , apoptosis , western blot , angiotensin converting enzyme 2 , lung , medicine , angiotensin ii , messenger rna , bleomycin , microbiology and biotechnology , andrology , biology , endocrinology , gene , blood pressure , biochemistry , chemotherapy , infectious disease (medical specialty) , disease , covid-19

Angiotensin converting enzyme 2 (ACE2) treatment suppresses the severity of acute lung injury (ALI). The effects of ACE2 in ALI have been shown to not only result from its antagonizing hydrolyzing angiotensin II (AngII), which is responsible for reduction in the vascular tension and pulmonary accumulation of inflammatory cells, but also result from a role of ACE2 in suppressing the ALI-induced apoptosis of pulmonary endothelial cells (PECs). Nevertheless, the underlying mechanisms of the role of ACE2 on PEC apoptosis are not completely understood.

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