Roles of Toll-like Receptor 7 and 8 in Prevention of Intrauterine Transmission of Hepatitis B Virus | Zendy

Ting Tian | Zendy; Dandan Sun | Zendy; Peng Wang | Zendy; Hanzhi Wang | Zendy; Xiaoxia Bai | Zendy; Xiaofu Yang | Zendy; Zhengping Wang | Zendy; Minyue Dong | Zendy

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Roles of Toll-like Receptor 7 and 8 in Prevention of Intrauterine Transmission of Hepatitis B Virus

Author(s) -

Ting Tian,

Dandan Sun,

Peng Wang,

Hanzhi Wang,

Xiaoxia Bai,

Xiaofu Yang,

Zhengping Wang,

Minyue Dong

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430367

Subject(s) - trophoblast , hepatitis b virus , placenta , transmission (telecommunications) , receptor , virology , hepatitis b , immunology , medicine , biology , virus , fetus , pregnancy , genetics , electrical engineering , engineering

Approximately 5% of newborns were infected by hepatitis B virus (HBV) via intrauterine transmission, but most of the infants born to HBV-positive mothers are protected from infection. However, the mechanisms by which intrauterine transmission is avoided remain elusive, and the roles of toll-like receptors (TLRs) have been proposed. The aims of this study were to clarify if TLR 7 and 8 are involved in the prevention of intrauterine transmission of HBV.

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