8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition | Zendy

Huan Yang | Zendy; Jing Xiong | Zendy; Wenjing Luo | Zendy; Jian Yang | Zendy; Tao Xi | Zendy

Open Access

8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition

Author(s) -

Huan Yang,

Jing Xiong,

Wenjing Luo,

Jian Yang,

Tao Xi

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430360

Subject(s) - apoptosis , reactive oxygen species , viability assay , cytochrome c , microbiology and biotechnology , intrinsic apoptosis , mapk/erk pathway , signal transduction , mtt assay , chemistry , flow cytometry , biology , programmed cell death , caspase , biochemistry

8-Methoxypsoralen (8-MOP), a formerly considered photosensitizing agent, induces apoptosis when used alone. On this basis, the present study was designed to explore the effects and mechanisms of 8-MOP-induced apoptosis in human hepatocellular carcinoma HepG2 cells, independent of its photoactivation.

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