Insulin-Like Growth Factor 1 Activates PI3k/Akt Signaling to Antagonize Lumbar Disc Degeneration | Zendy

Zuoqing Liu | Zendy; Kaihua Zhou | Zendy; Wen-Qin Fu | Zendy; Hailong Zhang | Zendy

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Insulin-Like Growth Factor 1 Activates PI3k/Akt Signaling to Antagonize Lumbar Disc Degeneration

Author(s) -

Zuoqing Liu,

Kaihua Zhou,

Wen-Qin Fu,

Hailong Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430347

Subject(s) - mmp3 , protein kinase b , pi3k/akt/mtor pathway , foxo1 , growth factor , insulin like growth factor , phosphorylation , cancer research , medicine , endocrinology , signal transduction , microbiology and biotechnology , chemistry , biology , receptor , gene expression , biochemistry , gene

The pathogenesis of Lumbar disc degeneration (LDD) has been extensively studied in the past. In particular, a role of matrix metalloproteinase 3 (MMP3) in the disease initiation and progression has been recently reported. However, an involvement of Insulin-like growth factor 1 (IGF-I)-stimulated phosphatidylinositol-3 kinase (PI3k) / Akt signaling pathway-mediated control of MMP3 in LDD has not been acknowledged.

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