DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain | Zendy

Takeshi Kanno | Zendy; Ayako Tsuchiya | Zendy; Tadashi Shimizu | Zendy; Miyuki Mabuchi | Zendy; Akito Tanaka | Zendy; Tomoyuki Nishizaki | Zendy

Open Access

DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain

Author(s) -

Takeshi Kanno,

Ayako Tsuchiya,

Tadashi Shimizu,

Miyuki Mabuchi,

Akito Tanaka,

Tomoyuki Nishizaki

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430344

Subject(s) - protein kinase c , förster resonance energy transfer , chemistry , phosphatidylserine , microbiology and biotechnology , cytosol , biophysics , biochemistry , kinase , fluorescence , biology , enzyme , phospholipid , physics , quantum mechanics , membrane

The linoleic acid derivative DCP-LA selectively and directly activates PKCε. The present study aimed at understanding the mechanism of DCP-LA-induced PKCε activation.

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