Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy
Author(s) -
Guoliang Jiang,
Hui Gong,
Yuhong Niu,
Chunjie Yang,
Shijun Wang,
Zhidan Chen,
Yong Ye,
Ning Zhou,
Guoping Zhang,
Junbo Ge,
Yunzeng Zou
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430337
Subject(s) - angiotensin ii , receptor , chemistry , muscle hypertrophy , transfection , angiotensin ii receptor type 1 , renin–angiotensin system , microbiology and biotechnology , medicine , endocrinology , biology , biochemistry , gene , blood pressure
Angiotensin II (AngII) type 1 receptor (AT1R) could be activated by mechanical stress without the involvement of AngII during the development of cardiac hypertrophy. We aimed to identify sensing sites of AT1R for activation by mechanical stretch.
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