IL-29 Enhances LPS/TLR4-Mediated Inflammation in Rheumatoid Arthritis | Zendy

Donghua Xu | Zendy; Shushan Yan | Zendy; Huijuan Wang | Zendy; GU Bingjie | Zendy; Keyi Sun | Zendy; Xiaofan Yang | Zendy; Bin Sun | Zendy; XiaoDong Wang | Zendy

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IL-29 Enhances LPS/TLR4-Mediated Inflammation in Rheumatoid Arthritis

Author(s) -

Donghua Xu,

Shushan Yan,

Huijuan Wang,

GU Bingjie,

Keyi Sun,

Xiaofan Yang,

Bin Sun,

XiaoDong Wang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430330

Subject(s) - tlr4 , inflammation , peripheral blood mononuclear cell , immunology , synovial fluid , medicine , rheumatoid arthritis , lipopolysaccharide , cytokine , tumor necrosis factor alpha , pathogenesis , arthritis , interleukin , receptor , toll like receptor , in vitro , chemistry , pathology , immune system , osteoarthritis , innate immune system , biochemistry , alternative medicine

Interleukin-29 (IL-29), a critical member of type III interferons (IFNs) family, has been implicated in protecting against viral infection and modulating autoimmune inflammation. Toll-like receptor 4 (TLR4) plays a crucial role in synovial inflammation and may contribute to the pathogenesis of rheumatology arthritis (RA). However, little is known about the modifying effect of IL-29 on TLR4-mediated inflammation in RA. We aim to investigate the potential association between IL-29 and TLR4 in RA.

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