Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats | Zendy

M. D. M. Cezar | Zendy; R. L. Damatto | Zendy; Luana Urbano Pagan | Zendy; A. R. R. Lima | Zendy; Paula Felippe Martinez | Zendy; Camila Bonomo | Zendy; C. M. Rosa | Zendy; Dijon Henrique Salomé de Campos | Zendy; Antônio Carlos Cicogna | Zendy; Mariana Janini Gomes | Zendy; S. A. Oliveira | Zendy; Daniella Audi Blotta | Zendy; Marina Politi Okoshi | Zendy; Katashi Okoshi | Zendy

Open Access

Early Spironolactone Treatment Attenuates Heart Failure Development by Improving Myocardial Function and Reducing Fibrosis in Spontaneously Hypertensive Rats

Author(s) -

M. D. M. Cezar,

R. L. Damatto,

Luana Urbano Pagan,

A. R. R. Lima,

Paula Felippe Martinez,

Camila Bonomo,

C. M. Rosa,

Dijon Henrique Salomé de Campos,

Antônio Carlos Cicogna,

Mariana Janini Gomes,

S. A. Oliveira,

Daniella Audi Blotta,

Marina Politi Okoshi,

Katashi Okoshi

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430310

Subject(s) - spironolactone , medicine , endocrinology , spontaneously hypertensive rat , myocardial fibrosis , heart failure , blood pressure , muscle hypertrophy , aldosterone , fibrosis , cardiac fibrosis , pressure overload , cardiac function curve , left ventricular hypertrophy , diastole , cardiac hypertrophy

We evaluated the role of the aldosterone blocker spironolactone in attenuating long-term pressure overload-induced cardiac remodeling and heart failure (HF) in spontaneously hypertensive rats (SHR).

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