Tsc1 is a Critical Regulator of Macrophage Survival and Function | Zendy

Chunmin Fang | Zendy; Juan Yu | Zendy; Yuechen Luo | Zendy; Song Chen | Zendy; Weiqiang Wang | Zendy; Chunxiao Zhao | Zendy; Zhina Sun | Zendy; Wantong Wu | Zendy; Wei Guo | Zendy; Zhongchao Han | Zendy; Xiao Hu | Zendy; Fang Liao | Zendy; Xiaoming Feng | Zendy

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Tsc1 is a Critical Regulator of Macrophage Survival and Function

Author(s) -

Chunmin Fang,

Juan Yu,

Yuechen Luo,

Song Chen,

Weiqiang Wang,

Chunxiao Zhao,

Zhina Sun,

Wantong Wu,

Wei Guo,

Zhongchao Han,

Xiao Hu,

Fang Liao,

Xiaoming Feng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430306

Subject(s) - tsc1 , phagocytosis , mtorc1 , microbiology and biotechnology , chemokine , apoptosis , chemotaxis , macrophage , biology , flow cytometry , cancer research , chemistry , pi3k/akt/mtor pathway , receptor , inflammation , immunology , signal transduction , in vitro , biochemistry

Tuberous sclerosis complex 1 (Tsc1) has been shown to regulate M1/M2 polarization of macrophages, but the precise roles of Tsc1 in the function and stability of macrophages are not fully understood. Here we show that Tsc1 is required for regulating the survival, migration and phagocytosis of macrophages.

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