Stimulation of Suicidal Erythrocyte Death by the Antimalarial Drug Mefloquine | Zendy

Rosi Bissinger | Zendy; Susanne Barking | Zendy; Kousi Alzoubi | Zendy; Guilai Liu | Zendy; Guoxing Liu | Zendy; Florian Läng | Zendy

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Stimulation of Suicidal Erythrocyte Death by the Antimalarial Drug Mefloquine

Author(s) -

Rosi Bissinger,

Susanne Barking,

Kousi Alzoubi,

Guilai Liu,

Guoxing Liu,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430305

Subject(s) - ceramide , phosphatidylserine , mefloquine , apoptosis , oxidative stress , annexin , reactive oxygen species , programmed cell death , extracellular , pharmacology , microbiology and biotechnology , chemistry , annexin a5 , biology , biophysics , biochemistry , phospholipid , membrane , plasmodium falciparum , immunology , malaria

The antimalarial drug mefloquine has previously been shown to stimulate apoptosis of nucleated cells. Similar to apoptosis, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and phospholipid scrambling of the erythrocyte cell membrane with phosphatidylserine translocation to the erythrocyte surface. Stimulators of eryptosis include oxidative stress, increase of cytosolic Ca2+-activity ([Ca2+]i), and ceramide.

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