MicroRNA-155 Promotes Atherosclerosis Inflammation via Targeting SOCS1 | Zendy

Yang� Yang | Zendy; Lixia Yang | Zendy; Xing Liang | Zendy; Guofu Zhu | Zendy

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MicroRNA-155 Promotes Atherosclerosis Inflammation via Targeting SOCS1

Author(s) -

Yang� Yang,

Lixia Yang,

Xing Liang,

Guofu Zhu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430303

Subject(s) - microrna , inflammation , suppressor of cytokine signaling 1 , mir 155 , chemokine , cancer research , biology , immunology , ectopic expression , immune system , cytokine , regulator , medicine , microbiology and biotechnology , suppressor , cell culture , genetics , gene

Accumulating evidence suggests that atherosclerotic progression depends on persistent and chronic inflammation in the arterial walls. MicroRNA-155 is reportedly involved in cardiovascular disease and has been implicated as a pro-inflammation regulator. Although some researchers have focused on microRNA-155 as an atherosclerosis regulator, the mechanisms by which microRNA-155 functions as a putative pro-atherosclerosis microRNA are largely unknown. This study aims to analyze microRNA-155's effects on atherosclerotic inflammation and to explore its mechanism.

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