Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children | Zendy

Lingling Lu | Zendy; Feng Wang | Zendy; Lulu He | Zendy; Yao Xue | Zendy; Yaping Wang | Zendy; Heng Zhang | Zendy; Liucheng Rong | Zendy; Meilin Wang | Zendy; Zhengdong Zhang | Zendy; Yongjun Fang | Zendy; Hongjun Miao | Zendy

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Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Author(s) -

Lingling Lu,

Feng Wang,

Lulu He,

Yao Xue,

Yaping Wang,

Heng Zhang,

Liucheng Rong,

Meilin Wang,

Zhengdong Zhang,

Yongjun Fang,

Hongjun Miao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430301

Subject(s) - genotype , three prime untranslated region , taqman , untranslated region , biology , cancer research , childhood leukemia , single nucleotide polymorphism , leukemia , gene , cell growth , transfection , apoptosis , genetics , microbiology and biotechnology , oncology , medicine , messenger rna , lymphoblastic leukemia , real time polymerase chain reaction

IGF1 is a key regulator in cell proliferation and apoptosis, and the 3' un-translated region (3'UTR) of the gene plays an important role in gene expression. For the first time, we explored the relationship between polymorphisms in the IGF1 3'UTR region and the risk of childhood acute lymphoblastic leukemia (ALL).

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