Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells | Zendy

Yu Sun | Zendy; Qifang Li | Zendy; Yan Jia | Zendy; Rong Hu | Zendy; Hong Jiang | Zendy

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Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells

Author(s) -

Yu Sun,

Qifang Li,

Yan Jia,

Rong Hu,

Hong Jiang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430300

Subject(s) - isoflurane , stromal cell , pi3k/akt/mtor pathway , downregulation and upregulation , ischemic preconditioning , protein kinase b , pharmacology , hypoxia (environmental) , medicine , bone marrow , anesthetic , stromal cell derived factor 1 , ischemia , chemistry , cxcr4 , microbiology and biotechnology , anesthesia , signal transduction , cancer research , immunology , receptor , biology , chemokine , biochemistry , oxygen , gene , organic chemistry

Preconditioning with the volatile anesthetic isoflurane exerts protective effects in animal models of ischemia. The cytoprotective effects of isoflurane are dependent on the expression of hypoxia inducible factor-1 (HIF-1), a dimeric transcription factor that mediates cellular responses to hypoxia.

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