Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction | Zendy

Chenhui Ju | Zendy; Xianpei Wang | Zendy; Chuanyu Gao | Zendy; Shuang-Xia Zhang | Zendy; Xinghua Ma | Zendy; Chang Liu | Zendy

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Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction

Author(s) -

Chenhui Ju,

Xianpei Wang,

Chuanyu Gao,

Shuang-Xia Zhang,

Xinghua Ma,

Chang Liu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430298

Subject(s) - blockade , fibrosis , heart failure , ventricular remodeling , myofibroblast , medicine , cardiac fibrosis , cardiology , myocardial infarction , myocardial fibrosis , receptor

After myocardial infarction (MI), cardiac fibrosis greatly contributes to left ventricular remodeling and heart failure. The intermediate-conductance calcium-activated potassium Channel (KCa3.1) has been recently proposed as an attractive target of fibrosis. The present study aimed to detect the effects of KCa3.1 blockade on ventricular remodeling following MI and its potential mechanisms.

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