IL10-Deficiency in CD4+ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis | Zendy

Virginia Seiffart | Zendy; Julia Zoeller | Zendy; Robert Klopfleisch | Zendy; Munisch Wadwa | Zendy; Wiebke Hansen | Zendy; Jan Buer | Zendy; Christian U. Riedel | Zendy; Astrid M. Westendorf | Zendy

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IL10-Deficiency in CD4+ T Cells Exacerbates the IFNγ and IL17 Response During Bacteria Induced Colitis

Author(s) -

Virginia Seiffart,

Julia Zoeller,

Robert Klopfleisch,

Munisch Wadwa,

Wiebke Hansen,

Jan Buer,

Christian U. Riedel,

Astrid M. Westendorf

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430295

Subject(s) - interleukin 10 , immunology , colitis , biology , citrobacter rodentium , immune system , inflammation , t cell , interleukin 17 , microbiology and biotechnology

IL10 is a key inhibitor of effector T cell activation and a mediator of intestinal homeostasis. In addition, IL10 has emerged as a key immunoregulator during infection with various pathogens, ameliorating the excessive T-cell responses that are responsible for much of the immunopathology associated with the infection. Because IL10 plays an important role in both intestinal homeostasis and infection, we studied the function of IL10 in infection-associated intestinal inflammation.

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