Carbon Monoxide Inhibits Receptor Activator of NF-κB (RANKL)-Induced Osteoclastogenesis
Author(s) -
Feng-Jen Tseng,
WeiTso Chia,
ChihHung Wang,
JiaFwu Shyu,
Guo-Hau Gou,
HaoAi Shui,
HueyKang Sytwu,
RuYu Pan,
ChingFeng Weng
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430294
Subject(s) - rankl , chemistry , troglitazone , osteoprotegerin , osteoclast , receptor , endocrinology , medicine , apoptosis , activator (genetics) , nf κb , proinflammatory cytokine , peroxisome proliferator activated receptor , cancer research , inflammation , biochemistry
Low concentrations of carbon monoxide (CO) have anti-inflammatory effects and can reduce bone erosion in a murine collagen-induced arthritis model. The objective of this study was to assess the effects of CO on receptor activator of NF-κB ligand (RANKL), one of the key stimulators of osteoclastogenesis.
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