Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a | Zendy

Yue-wen Chang | Zendy; Yongfang Zhao | Zendy; Wei Gu | Zendy; Yuelong Cao | Zendy; Shuqiang Wang | Zendy; Jian Pang | Zendy; Yin-yu Shi | Zendy

Open Access

Bufalin Inhibits the Differentiation and Proliferation of Cancer Stem Cells Derived from Primary Osteosarcoma Cells through Mir-148a

Author(s) -

Yue-wen Chang,

Yongfang Zhao,

Wei Gu,

Yuelong Cao,

Shuqiang Wang,

Jian Pang,

Yin-yu Shi

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430289

Subject(s) - bufalin , osteosarcoma , cancer research , cancer , cell growth , stem cell , cancer stem cell , microbiology and biotechnology , cancer cell , microrna , biology , chemistry , medicine , apoptosis , biochemistry , gene

Osteosarcoma (OS) is the second leading cause of cancer-related death in children and young adults. Chemoresistance is the most important cause of treatment failure in OS, largely resulting from presence of cancer stem cells (CSCs). However, CSCs isolated from cancer cell lines do not necessarily represent those from primary human tumors due to accumulation of genetic aberrations that increase with passage number. Therefore, studies on CSCs from primary OS may be more important for understanding the mechanisms driving the chemoresistance of CSCs in OS.

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