Upregulation of Death Receptor 5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate Cancer Cells to TRAIL Induced Apoptosis by Vitisin A | Zendy

Deokil Shin | Zendy; Hee Young Kwon | Zendy; Eun Jung Sohn | Zendy; Moon Sik Nam | Zendy; Jung Hyo Kim | Zendy; JaeChul Lee | Zendy; ShiYong Ryu | Zendy; Byungchun Park | Zendy; SungHoon Kim | Zendy

Open Access

Upregulation of Death Receptor 5 and Production of Reactive Oxygen Species Mediate Sensitization of PC-3 Prostate Cancer Cells to TRAIL Induced Apoptosis by Vitisin A

Author(s) -

Deokil Shin,

Hee Young Kwon,

Eun Jung Sohn,

Moon Sik Nam,

Jung Hyo Kim,

JaeChul Lee,

ShiYong Ryu,

Byungchun Park,

SungHoon Kim

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430286

Subject(s) - du145 , lncap , apoptosis , cancer research , flow cytometry , prostate cancer , annexin , cancer cell , chemistry , reactive oxygen species , cytotoxic t cell , population , biology , cancer , microbiology and biotechnology , medicine , biochemistry , in vitro , environmental health

Although Vitisin A, derived from wine grapes, is known to have cytotoxic, anti-adipogenic, anti-inflammatory and antioxidant effects, the underlying antitumor mechanism has not been investigated in prostate cancer cells to date. In the present study, the apoptotic mechanism of Vitisin A plus TNF-related apoptosis-inducing ligand (TRAIL) in prostate cancer cells was elucidated.

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