Metoprolol Inhibits Cardiac Apoptosis and Fibrosis in a Canine Model of Chronic Obstructive Sleep Apnea | Zendy

Wenpeng Li | Zendy; Sen Yan | Zendy; Jing Zhao | Zendy; Xue Ding | Zendy; Song Zhang | Zendy; Dingyu Wang | Zendy; Lei Liu | Zendy; Wenpeng Peng | Zendy; Hui Li | Zendy; Dongyang Wang | Zendy; Zhaorui Liu | Zendy; Yue Li | Zendy

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Metoprolol Inhibits Cardiac Apoptosis and Fibrosis in a Canine Model of Chronic Obstructive Sleep Apnea

Author(s) -

Wenpeng Li,

Sen Yan,

Jing Zhao,

Xue Ding,

Song Zhang,

Dingyu Wang,

Lei Liu,

Wenpeng Peng,

Hui Li,

Dongyang Wang,

Zhaorui Liu,

Yue Li

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430284

Subject(s) - metoprolol , medicine , tunel assay , cardiac fibrosis , fibrosis , endocrinology , downregulation and upregulation , cardiology , biology , immunohistochemistry , biochemistry , gene

Emerging evidence suggested that obstructive sleep apnea (OSA) was independently associated with the development of heart failure. In this study, we explored the influence of chronic OSA on left ventricular structural remodeling in canines, and the potential therapeutical role of metoprolol.

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