Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes | Zendy

Weiwei Dai | Zendy; Stéphane Panserat | Zendy; Elisabeth PlagnesJuan | Zendy; Iban Seiliez | Zendy; Sandrine SkibaCassy | Zendy

Open Access

Amino Acids Attenuate Insulin Action on Gluconeogenesis and Promote Fatty Acid Biosynthesis via mTORC1 Signaling Pathway in trout Hepatocytes

Author(s) -

Weiwei Dai,

Stéphane Panserat,

Elisabeth PlagnesJuan,

Iban Seiliez,

Sandrine SkibaCassy

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430281

Subject(s) - mtorc1 , phosphorylation , ribosomal protein s6 , p70 s6 kinase 1 , biology , protein kinase b , gluconeogenesis , ribosomal s6 kinase , biochemistry , protein kinase a , mapk/erk pathway , amp activated protein kinase , insulin , ampk , endocrinology , metabolism

Carnivores exhibit poor utilization of dietary carbohydrates and glucose intolerant phenotypes, yet it remains unclear what are the causal factors and underlying mechanisms. We aimed to evaluate excessive amino acids (AAs)-induced effects on insulin signaling, fatty acid biosynthesis and glucose metabolism in rainbow trout and determine the potential involvement of mTORC1 and p38 MAPK pathway.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research