Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models | Zendy

Dan Zheng | Zendy; Shiyun Dong | Zendy; Ting Li | Zendy; Fan Yang | Zendy; Xiangjing Yu | Zendy; Jichao Wu | Zendy; Xin Zhong | Zendy; Yajun Zhao | Zendy; Lina Wang | Zendy; Changqing Xu | Zendy; Fanghao Lu | Zendy; Weihua Zhang | Zendy

Open Access

Exogenous Hydrogen Sulfide Attenuates Cardiac Fibrosis Through Reactive Oxygen Species Signal Pathways in Experimental Diabetes Mellitus Models

Author(s) -

Dan Zheng,

Shiyun Dong,

Ting Li,

Fan Yang,

Xiangjing Yu,

Jichao Wu,

Xin Zhong,

Yajun Zhao,

Lina Wang,

Changqing Xu,

Fanghao Lu,

Weihua Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430266

Subject(s) - nox4 , diabetic cardiomyopathy , cardiac fibrosis , myocardial fibrosis , nadph oxidase , reactive oxygen species , oxidative stress , fibrosis , cystathionine beta synthase , medicine , endocrinology , cardiomyopathy , streptozotocin , chemistry , diabetes mellitus , biochemistry , heart failure , enzyme , cysteine

Oxidative stress inducing hyperglycemia and high glucose play an important role in the development of cardiac fibrosis associated with diabetic cardiomyopathy. The endogenous gasotransmitter hydrogen sulfide (H2S) can act in a cytoprotective manner. However, whether H2S could inhibit the fibrotic process is unclear. The purpose of our study was to examine the role of H2S in the development and underlying mechanisms behind diabetic cardiomyopathy.

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