NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway | Zendy

Tian-Jun Chen | Zendy; Yuefei Zhou | Zendy; Jie-Juan Ning | Zendy; Yang Tian | Zendy; Hui Ren | Zendy; Yang Li | Zendy; Shuo Zhang | Zendy; Mingwei Chen | Zendy

Open Access

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway

Author(s) -

Tian-Jun Chen,

Yuefei Zhou,

Jie-Juan Ning,

Yang Tian,

Hui Ren,

Yang Li,

Shuo Zhang,

Mingwei Chen

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430264

Subject(s) - cisplatin , ampk , mapk/erk pathway , protein kinase b , a549 cell , chemistry , apoptosis , cell growth , cell cycle , pharmacology , cancer research , kinase , microbiology and biotechnology , protein kinase a , biology , biochemistry , chemotherapy , genetics

Drug combination therapies using cisplatin and natural products are common practice in the treatment of human lung cancer. Osthole is a natural compound extracted from a number of medicinal plants and has been shown to exert strong anticancer activities with low toxicity.

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