Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia | Zendy

Anke Zieseniß | Zendy; Amke Hesse | Zendy; Aline Jatho | Zendy; Sabine Krull | Zendy; M. Hölscher | Zendy; Sabine Vogel | Zendy; Dörthe M. Katschinski | Zendy

Open Access

Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia

Author(s) -

Anke Zieseniß,

Amke Hesse,

Aline Jatho,

Sabine Krull,

M. Hölscher,

Sabine Vogel,

Dörthe M. Katschinski

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430260

Subject(s) - cardioprotection , ligation , transgene , ischemia , cardiac function curve , context (archaeology) , genetically modified mouse , medicine , endocrinology , biology , heart failure , gene , biochemistry , paleontology

The prolyl-4-hydroxylase domain (PHD) enzymes are representing novel therapeutic targets for ischemic tissue protection. Whereas the consequences of a knock out of the PHDs have been analyzed in the context of cardioprotection, the implications of PHD overexpression is unknown so far.

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