Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling | Zendy

Nayyar Ahmed | Zendy; Pathum Dhanapala | Zendy; Cenk Suphioglu | Zendy

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Identification and Characterization of a Novel IL-4 Receptor α Chain (IL-4Rα) Antagonist to Inhibit IL-4 Signalling

Author(s) -

Nayyar Ahmed,

Pathum Dhanapala,

Cenk Suphioglu

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430259

Subject(s) - phage display , peptide , receptor , in vitro , interleukin 4 , cytokine , hek 293 cells , peptide library , chemistry , immunoglobulin e , microbiology and biotechnology , biology , antibody , immunology , peptide sequence , biochemistry , gene

In recent times, allergy has become a financial, physical and psychological burden to the society as a whole. In allergic cascades, cytokine IL-4 binds to IL-4 receptor (IL-4R), consequently producing allergen-specific IgE antibodies by B cells. In addition, among other functions, IL-4 is also responsible for B and T cell proliferation and differentiation. Hence, characterization of novel antagonists that inhibit IL-4 signalling forms the overall aim of this study.

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