Changes in T-Tubules and Sarcoplasmic Reticulum in Ventricular Myocytes in Early Cardiac Hypertrophy in a Pressure Overload Rat Model | Zendy

Perla Pérez-Treviño | Zendy; Jorge Pérez-Treviño | Zendy; Cuauhtémoc Borja-Villa | Zendy; Noemı́ Garcı́a | Zendy; Julio Altamirano | Zendy

Open Access

Changes in T-Tubules and Sarcoplasmic Reticulum in Ventricular Myocytes in Early Cardiac Hypertrophy in a Pressure Overload Rat Model

Author(s) -

Perla Pérez-Treviño,

Jorge Pérez-Treviño,

Cuauhtémoc Borja-Villa,

Noemı́ Garcı́a,

Julio Altamirano

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430254

Subject(s) - medicine , muscle hypertrophy , myocyte , pressure overload , contractility , endoplasmic reticulum , endocrinology , heart failure , fluorescence recovery after photobleaching , chemistry , biology , microbiology and biotechnology , cardiac hypertrophy , biochemistry , membrane

Pressure-overload (PO) causes cardiac hypertrophy (CH), and eventually leads to heart failure (HF). HF ventricular myocytes present transverse-tubules (TT) loss or disarrangement and decreased sarcoplasmic reticulum (SR) density, and both contribute to altered Ca2+ signaling and heart dysfunction. It has been shown that TT remodeling precedes HF, however, it is unknown whether SR structural and functional remodeling also starts early in CH.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research