Activation of the ALK-5 Pathway is not per se Sufficient for the Antiproliferative Effect of TGF-β1 on Renal Tubule Epithelial Cells | Zendy

Omar García-Sánchez | Zendy; Sandra M. SanchoMartínez | Zendy; José M. LópezNovoa | Zendy; Francisco J. LópezHernández | Zendy

Open Access

Activation of the ALK-5 Pathway is not per se Sufficient for the Antiproliferative Effect of TGF-β1 on Renal Tubule Epithelial Cells

Author(s) -

Omar García-Sánchez,

Sandra M. SanchoMartínez,

José M. LópezNovoa,

Francisco J. LópezHernández

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430246

Subject(s) - microbiology and biotechnology , cancer research , cell growth , cell cycle , signal transduction , mapk/erk pathway , chemistry , apoptosis , biology , biochemistry

Defective tissue repair underlies renal tissue degeneration during chronic kidney disease (CKD) progression. Unbalanced presence of TGF-β opposes effective cell proliferation and differentiation processes, necessary to replace damaged epithelia. TGF-β also retains arrested cells in a fibrotic phenotype responsible for irreversible scarring. In order to identify prospective molecular targets to prevent the effect of TGF-β during CKD, we studied the signaling pathways responsible for the antiproliferative effect of this cytokine.

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