The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair | Zendy

Songliu Hu | Zendy; Songbin Fu | Zendy; Xiangying Xu | Zendy; Lin Chen | Zendy; Jianyu Xu | Zendy; Bin Li | Zendy; Yuanyuan Qu | Zendy; Hongyang Yu | Zendy; Shan Lü | Zendy; Wenxin Li | Zendy

Open Access

The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

Author(s) -

Songliu Hu,

Songbin Fu,

Xiangying Xu,

Lin Chen,

Jianyu Xu,

Bin Li,

Yuanyuan Qu,

Hongyang Yu,

Shan Lü,

Wenxin Li

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430245

Subject(s) - survivin , dna repair , dna damage , microbiology and biotechnology , cancer research , clonogenic assay , biology , radiosensitivity , chemistry , apoptosis , dna , medicine , biochemistry , radiation therapy

Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We investigated the effects of YM155, a small molecule inhibitor of survivin expression, on the radiosensitivity of human non-small cell lung cancer (NSCLC) cell lines and elucidated a relationship between the cellular localization of survivin and DNA double-strand break repair.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research