Placental Growth Factor Promotes Metastases of Non-Small Cell Lung Cancer Through MMP9
Author(s) -
Wei Zhang,
Ting Zhang,
Yuqing Lou,
Bo Yan,
Shaohua Cui,
Liyan Jiang,
Baohui Han
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430244
Subject(s) - placental growth factor , cancer research , medicine , lung cancer , growth factor , mmp9 , cancer , lung , cell growth , oncology , pathology , biology , vascular endothelial growth factor , downregulation and upregulation , vegf receptors , receptor , biochemistry , genetics , gene
Neovascularization and invasion coordinate cancer metastases in non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms are poorly understood. Recently, a substantial role of placental growth factor (PLGF) in cancer cell invasion has been acknowledged in several types of cancer, whereas a possible involvement of PLGF in the metastases of NSCLC has not been studied.
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