Stimulating Effect of a Newly Synthesized Sulfonamido-Basedgallate on Articular Chondrocytes in Vitro | Zendy

Zhenhui Lu | Zendy; Liqin Wang | Zendy; Hongmei Pan | Zendy; Xiao Lin | Zendy; CuiWu Lin | Zendy; Buming Liu | Zendy; Li Zheng | Zendy; Jinmin Zhao | Zendy

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Stimulating Effect of a Newly Synthesized Sulfonamido-Basedgallate on Articular Chondrocytes in Vitro

Author(s) -

Zhenhui Lu,

Liqin Wang,

Hongmei Pan,

Xiao Lin,

CuiWu Lin,

Buming Liu,

Li Zheng,

Jinmin Zhao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430243

Subject(s) - wnt signaling pathway , chondrocyte , aggrecan , microbiology and biotechnology , chemistry , cyclin d1 , cartilage , gsk 3 , catenin , signal transduction , in vitro , biology , cell , biochemistry , medicine , pathology , anatomy , cell cycle , articular cartilage , osteoarthritis , alternative medicine

The phenotype of chondrocyte is easy to be lost when expanded in vitro by a process defined "dedifferentiation". Traditional growth factors such as transforming growth factor (TGF-β1) are effective in preventing of dedifferentiation, but high costs and loss of activity limited their use. It is of significance to find substitutes which can reduce dedifferentiation and preserve chondrocytes phenotype to ensure sufficient differentiated cells for further study.

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