Placental Growth Factor Promotes Metastases of Ovarian Cancer Through MiR-543-Regulated MMP7 | Zendy

Ning Song | Zendy; Hao Liu | Zendy; Xiaoxin Ma | Zendy; Shulan Zhang | Zendy

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Placental Growth Factor Promotes Metastases of Ovarian Cancer Through MiR-543-Regulated MMP7

Author(s) -

Ning Song,

Hao Liu,

Xiaoxin Ma,

Shulan Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430235

Subject(s) - placental growth factor , ovarian cancer , microrna , medicine , andrology , cancer research , biology , cancer , vascular endothelial growth factor , gene , vegf receptors , genetics

Elucidation of the molecular mechanisms underlying ovarian cancer (OC) cell invasion and migration may provide important evidence for developing efficient therapy. Recently, Matrix metalloproteinase (MMP) has been shown to be regulated by vascular endothelial growth factor family members, especially placental growth factor (PLGF), as a potential mechanism underlying cancer invasion. Here, we studied the molecular relationship between PLGF and MMP7 in the OC.

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