Open AccessMiR-423-3p Enhances Cell Growth Through Inhibition of p21Cip1/Waf1 in Colorectal Cancer
Author(s) -
Hongtao Li,
Hui Zhang,
Yong Chen,
Xianfu Liu,
Jun Qian
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430230
Subject(s) - cell growth , carcinogenesis , oncogene , cancer research , colorectal cancer , microrna , cell cycle , biology , cell , in vivo , cancer , gene , genetics
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally, with many oncogenes and tumor suppressors involved. The miRNAs are small non-coding RNAs known to play a vital role in the pathogenesis of CRC. The miR-423-3p was reported to act as an oncogene; however, its role in CRC growth remains unknown.
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