The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs | Zendy

Ningning Liu | Zendy; Ning Zhao | Zendy; Na Cai | Zendy

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The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs

Author(s) -

Ningning Liu,

Ning Zhao,

Na Cai

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430225

Subject(s) - survivin , western blot , hypoxia (environmental) , cyclooxygenase , umbilical vein , chemistry , hypoxia inducible factors , angiogenesis , prostaglandin e2 , microbiology and biotechnology , cancer research , biology , apoptosis , endocrinology , biochemistry , enzyme , organic chemistry , oxygen , in vitro , gene

To investigate the roles of hypoxia-inducible factor 1α (HIF-1α), cyclooxygenase-2 (Cox-2) and its product, Prostaglandin E2 (PGE2), in the mechanisms underlying hypoxia-induced survivin expression in human umbilical vein endothelial cells (HUVECs) and to examine the effect of celecoxib, a selective Cox-2 inhibitor, on survivin expression.

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