Inhibitory Effect of NH4Cl Treatment on Renal Tgfß1 Signaling Following Unilateral Ureteral Obstruction | Zendy

Martina Feger | Zendy; Ioana Alesutan | Zendy; Tatsiana Castor | Zendy; Sobuj Mia | Zendy; Katharina Musculus | Zendy; Jakob Voelkl | Zendy; Florian Läng | Zendy

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Inhibitory Effect of NH4Cl Treatment on Renal Tgfß1 Signaling Following Unilateral Ureteral Obstruction

Author(s) -

Martina Feger,

Ioana Alesutan,

Tatsiana Castor,

Sobuj Mia,

Katharina Musculus,

Jakob Voelkl,

Florian Läng

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430222

Subject(s) - medicine , signal transduction , transforming growth factor , urology , endocrinology , pharmacology , biology , microbiology and biotechnology

Consequences of obstructive nephropathy include tissue fibrosis, a major pathophysiological mechanism contributing to development of end-stage renal disease. Transforming growth factor β 1 (Tgfβ1) is involved in the progression of renal fibrosis. According to recent observations, ammonium chloride (NH4Cl) prevented phosphate-induced vascular remodeling, effects involving decrease of Tgfβ1 expression and inhibition of Tgfβ1-dependent signaling. The present study, thus, explored whether NH4Cl influences renal Tgfβ1-induced pro-fibrotic signaling in obstructive nephropathy induced by unilateral ureteral obstruction (UUO).

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