Formononetin Induces Apoptosis of Human Osteosarcoma Cell Line U2OS by Regulating the Expression of Bcl-2, Bax and MiR-375 In Vitro and In Vivo | Zendy

Wei Hu | Zendy; Zengming Xiao | Zendy

Open Access

Formononetin Induces Apoptosis of Human Osteosarcoma Cell Line U2OS by Regulating the Expression of Bcl-2, Bax and MiR-375 In Vitro and In Vivo

Author(s) -

Wei Hu,

Zengming Xiao

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430220

Subject(s) - formononetin , apoptosis , in vivo , cell growth , cell culture , flow cytometry , in vitro , chemistry , western blot , cell , cancer research , mtt assay , microbiology and biotechnology , biology , biochemistry , genistein , endocrinology , daidzein , genetics , gene

Phytoestrogens are known to prevent tumor progression by inhibiting proliferation and inducing apoptosis in cancer cells. Formononetin is one of the main components of red clover plants, and is considered as a typical phytoestrogen. This study investigates formononetin induction of apoptosis of human osteosarcoma cell line U2OS by regulating Bcl-2 and Bax expression in vitro and in vivo.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research