Combinatorial MicroRNAs Suppress Hypoxia-Induced Cardiomyocytes Apoptosis
Author(s) -
Yingqi Xu,
Wenliang Zhu,
Zhe Wang,
Wei Yuan,
Yong Sun,
Huibin Liu,
Zhimin Du
Publication year - 2015
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000430219
Subject(s) - apoptosis , hypoxia (environmental) , tunel assay , microrna , terminal deoxynucleotidyl transferase , downregulation and upregulation , flow cytometry , blot , protein kinase b , microbiology and biotechnology , viability assay , biology , chemistry , biochemistry , gene , organic chemistry , oxygen
Our previous in silico analysis revealed potential synergy in the activities of micro(mi)RNAs in myocardial infarction. The present study investigated whether miR-1 and -21 act synergistically to protect against cardiomyocytes apoptosis.
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