MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-β1/Smad-Independent Pathway in Patients with Coronary Heart Disease | Zendy

Sihui Li | Zendy; Qian Fan | Zendy; Shaolin He | Zendy; Tingting Tang | Zendy; Yuhua Liao | Zendy; Jiang-jiao Xie | Zendy

Open Access

MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-β1/Smad-Independent Pathway in Patients with Coronary Heart Disease

Author(s) -

Sihui Li,

Qian Fan,

Shaolin He,

Tingting Tang,

Yuhua Liao,

Jiang-jiao Xie

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430214

Subject(s) - foxp3 , microrna , smad , flow cytometry , peripheral blood mononuclear cell , medicine , transforming growth factor , immunology , context (archaeology) , il 2 receptor , myocardial infarction , unstable angina , proinflammatory cytokine , real time polymerase chain reaction , transforming growth factor beta , regulatory t cell , transfection , inflammation , cancer research , biology , t cell , immune system , cell culture , gene , paleontology , biochemistry , in vitro , genetics

CD4+CD25+FoxP3+ regulatory T cells (Treg cells) play a protective role against the development and progression of the inflammatory disease atherosclerosis (AS). MicroRNA-21 (miR-21) is expressed in Treg cells and is up-regulated in the context of AS and other inflammatory diseases.

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