Effect of Salusin-ß on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism | Zendy

Xiaole Xu | Zendy; Mengzi He | Zendy; Tingting Liu | Zendy; Yi Zeng | Zendy; Wei Zhang | Zendy

Open Access

Effect of Salusin-ß on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism

Author(s) -

Xiaole Xu,

Mengzi He,

Tingting Liu,

Yi Zeng,

Wei Zhang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430207

Subject(s) - gene knockdown , vascular smooth muscle , peroxisome proliferator activated receptor , transfection , gene expression , receptor , biology , hdac3 , nuclear receptor , inflammation , signal transduction , microbiology and biotechnology , endocrinology , medicine , chemistry , cancer research , transcription factor , histone deacetylase , gene , histone , immunology , biochemistry , smooth muscle

salusin-β is considered to be a potential pro-atherosclerotic factor. Regulation and function of vascular smooth muscle cells (VSMCs) are important in the progression of atherosclerosis. Peroxisome proliferator-activated receptor gamma (PPARγ) exerts a vascular protective role beyond its metabolic effects. Salusin-β has direct effects on VSMCs. The aim of the present study was to assess the effect of salusin-β on PPARγ gene expression in primary cultured rat VSMCs.

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