Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation | Zendy

Huaming Xue | Zendy; Yihui Tu | Zendy; Tong Ma | Zendy; Xiaodong Liu | Zendy; Tao Wen | Zendy; Minwei Cai | Zendy; Zhidao Xia | Zendy; Jiong Mei | Zendy

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Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation

Author(s) -

Huaming Xue,

Yihui Tu,

Tong Ma,

Xiaodong Liu,

Tao Wen,

Minwei Cai,

Zhidao Xia,

Jiong Mei

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430206

Subject(s) - lactoferrin , apoptosis , microbiology and biotechnology , chemistry , cancer research , signal transduction , interleukin 1β , akt1 , interleukin , medicine , cytokine , biology , protein kinase b , biochemistry

Chondrocyte apoptosis is largely responsible for cartilage degeneration in osteoarthritis (OA). Interleukin-1 beta (IL-1β) is widely used as a chondrocyte apoptosis-inducing agent, while lactoferrin (LF) is an anabolic reagent which has the potential to inhibit chondrocyte apoptosis. We assessed the effects of LF on cartilage degeneration in IL-1β-induced chondrocytes and in a rat model of OA, and explored the potential molecular mechanisms involved.

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