Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection | Zendy

Katja Merches | Zendy; Vishal Khairnar | Zendy; Torben Knuschke | Zendy; Namir Shaabani | Zendy; Nadine Honke | Zendy; Vikas Duhan | Zendy; Mike Recher | Zendy; Alexander A. Navarini | Zendy; Cornelia Hardt | Zendy; Dieter Häussinger | Zendy; Burkhard Tümmler | Zendy; Erich Gulbins | Zendy; Anthony H. Futerman | Zendy; Daniel Hoffmann | Zendy; Florian Läng | Zendy; Philipp A. Lang | Zendy; Astrid M. Westendorf | Zendy; Karl S. Lang | Zendy

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Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection

Author(s) -

Katja Merches,

Vishal Khairnar,

Torben Knuschke,

Namir Shaabani,

Nadine Honke,

Vikas Duhan,

Mike Recher,

Alexander A. Navarini,

Cornelia Hardt,

Dieter Häussinger,

Burkhard Tümmler,

Erich Gulbins,

Anthony H. Futerman,

Daniel Hoffmann,

Florian Läng,

Philipp A. Lang,

Astrid M. Westendorf,

Karl S. Lang

Publication year - 2015

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000430200

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , virus , interferon , biology , viremia , virology , neutropenia , lymphocytic choriomeningitis , virulence , lysozyme , immunology , bacteria , immune system , gene , cd8 , chemotherapy , biochemistry , genetics

Type I interferon (IFN-I) predisposes to bacterial superinfections, an important problem during viral infection or treatment with interferon-alpha (IFN-α). IFN-I-induced neutropenia is one reason for the impaired bacterial control; however there is evidence that more frequent bacterial infections during IFN-α-treatment occur independently of neutropenia.

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